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Prednisone is also synthesized by microbiological dehydrogenation of cortisone. It raises glucose levels in the blood, increases potassium secretion, and reduces sodium secretion from the organism. Prednisolone is used for the same indications as all corticosteroids: Next, the resulting epoxide is reacted with methylmagnesium bromide, and sub- sequent removal of the ketal protection by hydrogen reduction gives the 5-hydroxy-6-methyl derivative of dihydrocortisone 27.

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Alkaline hydrolysis of the acetyl group of this compound leads to the desired aldosterone 27, Where To Order Lasix Online Safe. Reacting this with isopropenylacetate in the presence of p-toluenesulfonic acid gives the enolacetate 27. Treating the resulting enolacetate with iodosuccinimide, which reacts exclusively with the enolacetate double bond, an iodoketone is where To Order Lasix Online Safe, which is reacted with potassium acetate to form the acetate 27.

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